Indole carboxylic acid esters of melampomagnolide B are potent anticancer agents against both hematological and solid tumor cells
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چکیده
منابع مشابه
Fe3O4@silica sulfuric acid nanoparticles as a potent and recyclable solid acid catalyst for the synthesis of indole derivatives
Fe3O4 magnetic nanoparticles were synthesized by co-precipitation of Fe2+ and Fe3+ in aqueous NaOH. Then silica was coated on the obtained nanoparticles and the whole composite was functionalized with chlorosulfonic acid in CH2Cl2. The obtained nanocomposite (Fe3O4@SiO2-SO3H) was characterized by FT-IR, VSM and XRD techniques and was used as an efficient catalyst in condensation reaction of ind...
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The alkylating agent bendamustine is approved for the treatment of hematopoietic malignancies such as non-Hodgkin lymphoma, chronic lymphocytic leukemia and multiple myeloma. As preliminary data on recently disclosed bendamustine esters suggested increased cytotoxicity, we investigated representative derivatives in more detail. Especially basic esters, which are positively charged under physiol...
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متن کاملAssembly of indole-2-carboxylic acid esters through a ligand-free copper-catalysed cascade process.
A straightforward synthesis of indole-2-carboxylic esters was developed through a ligand-free copper-catalysed condensation/coupling/deformylation cascade process from 2-halo aryl aldehydes or ketones with ethyl isocyanoacetate. The reactions proceeded well for most of the 2-iodo-, bromo-, and chloro-substrates under room temperature or mild conditions.
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Objective There is an urgent need drugs against particularly difficult to treat solid tumors such as pancreatic, triple negative breast, lung, colon, metastatic prostate cancers and melanoma. Thus, the objective of this study was to synthesize compounds based computational modeling that indicated the pyrido[3,4-b]indole class bind to MDM2, a new cancer target for which there are still no drug o...
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ژورنال
عنوان ژورنال: European Journal of Medicinal Chemistry
سال: 2017
ISSN: 0223-5234
DOI: 10.1016/j.ejmech.2017.05.031